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Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure

Widespread changes in cardiac gene expression occur during heart failure, yet the mechanisms responsible for coordinating these changes remain poorly understood. The Mediator complex represents a nodal point for modulating transcription by bridging chromatin-bound transcription factors with RNA poly...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Hall, Duane D., Ponce, Jessica M., Chen, Biyi, Spitler, Kathryn M., Alexia, Adrianne, Oudit, Gavin Y., Song, Long-Sheng, Grueter, Chad E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543923/
https://ncbi.nlm.nih.gov/pubmed/28768905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92476
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