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Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming
The mediator complex, a multisubunit nuclear complex, plays an integral role in regulating gene expression by acting as a bridge between transcription factors and RNA polymerase II. Genetic deletion of mediator subunit 1 (Med1) results in embryonic lethality, due in large part to impaired cardiac de...
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| Publicado no: | Am J Physiol Heart Circ Physiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5407164/ https://ncbi.nlm.nih.gov/pubmed/28159809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00728.2016 |
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