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Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming

The mediator complex, a multisubunit nuclear complex, plays an integral role in regulating gene expression by acting as a bridge between transcription factors and RNA polymerase II. Genetic deletion of mediator subunit 1 (Med1) results in embryonic lethality, due in large part to impaired cardiac de...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Heart Circ Physiol
Prif Awduron: Spitler, Kathryn M., Ponce, Jessica M., Oudit, Gavin Y., Hall, Duane D., Grueter, Chad E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407164/
https://ncbi.nlm.nih.gov/pubmed/28159809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00728.2016
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