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PD-L1 immune suppression in cancer: Tumor cells or host cells?

Four recent publications reported the role of PD-L1 expression on host versus malignant cells within the tumor for PD-1/PD-L1 checkpoint blockade therapy. All four research groups harmoniously report: PD-L1 expressed by both host as well as tumor cells are capable of suppressing T cell functions. Th...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Kleinovink, Jan Willem, van Hall, Thorbald, Ossendorp, Ferry, Fransen, Marieke F.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543902/
https://ncbi.nlm.nih.gov/pubmed/28811961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1325982
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