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Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

PD-1 is a receptor of the Ig superfamily that negatively regulates T cell antigen receptor signaling by interacting with the specific ligands (PD-L) and is suggested to play a role in the maintenance of self-tolerance. In the present study, we examined possible roles of the PD-1/PD-L system in tumor...

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Hlavní autoři: Iwai, Yoshiko, Ishida, Masayoshi, Tanaka, Yoshimasa, Okazaki, Taku, Honjo, Tasuku, Minato, Nagahiro
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC129438/
https://ncbi.nlm.nih.gov/pubmed/12218188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192461099
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