The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

Signaling through the programmed death 1 (PD-1) inhibitory receptor upon binding its ligand, PD-L1, suppresses immune responses against autoantigens and tumors and plays an important role in the maintenance of peripheral immune tolerance. Release from PD-1 inhibitory signaling revives “exhausted” vi...

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Detalhes bibliográficos
Main Authors: Lin, David Yin-wei, Tanaka, Yoshimasa, Iwasaki, Masashi, Gittis, Apostolos G., Su, Hua-Poo, Mikami, Bunzo, Okazaki, Taku, Honjo, Tasuku, Minato, Nagahiro, Garboczi, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268576/
https://ncbi.nlm.nih.gov/pubmed/18287011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712278105
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