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Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

PD-1 is an immunoglobulin superfamily member bearing an immunoreceptor tyrosine-based inhibitory motif, and disruption of the PD-1 gene results in the development of lupus-like autoimmune diseases. In this study, we examined effects of the PD-1 deficiency on the thymocyte differentiation at the clon...

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Detalhes bibliográficos
Main Authors: Nishimura, Hiroyuki, Honjo, Tasuku, Minato, Nagahiro
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195853/
https://ncbi.nlm.nih.gov/pubmed/10704469
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