Phase I study of glasdegib (PF‐04449913), an oral smoothened inhibitor, in Japanese patients with select hematologic malignancies

The hedgehog signaling pathway regulates multiple morphogenetic processes during embryogenesis. Aberrant activation of the hedgehog pathway signal transduction in adult tissues is associated with the pathogenesis of hematologic malignancies and solid tumors. We report findings from an open‐label, mu...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Minami, Yosuke, Minami, Hironobu, Miyamoto, Toshihiro, Yoshimoto, Goichi, Kobayashi, Yukio, Munakata, Wataru, Onishi, Yasushi, Kobayashi, Masahiro, Ikuta, Mari, Chan, Geoffrey, Woolfson, Adrian, Ono, Chiho, Shaik, Mohammed Naveed, Fujii, Yosuke, Zheng, Xianxian, Naoe, Tomoki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543507/
https://ncbi.nlm.nih.gov/pubmed/28556364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13285
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