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Evaluation of the effect of rifampin on the pharmacokinetics of the Smoothened inhibitor glasdegib in healthy volunteers
AIMS: This study aimed to evaluate the effect of a strong CYP3A inducer, rifampin, on glasdegib pharmacokinetics in healthy volunteers. METHODS: In an open‐label, fixed‐sequence, two‐period Phase 1 study, subjects received a single 100‐mg oral dose of glasdegib alone or following once‐daily pre‐trea...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5980541/ https://ncbi.nlm.nih.gov/pubmed/29488303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13568 |
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