Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway

Deficiency of factor X (F10) in humans is a rare bleeding disorder with a heterogeneous phenotype and limited therapeutic options. Targeted disruption of F10 and other common pathway factors in mice results in embryonic/neonatal lethality with rapid resorption of homozygous mutants, hampering additi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Hu, Zhilian, Liu, Yang, Huarng, Michael C., Menegatti, Marzia, Reyon, Deepak, Rost, Megan S., Norris, Zachary G., Richter, Catherine E., Stapleton, Alexandra N., Chi, Neil C., Peyvandi, Flora, Joung, J. Keith, Shavit, Jordan A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542852/
https://ncbi.nlm.nih.gov/pubmed/28576875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-765206
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