A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis

Plasma fibrinogen molecules comprise 2 copies of Aα, Bβ, and γ chains folded into a hexameric protein. A minor fibrinogen isoform with an extended Aα chain (AαE) is more abundant in newborn human blood than in adults. Larval zebrafish produce predominantly AαE-containing fibrinogen, but its function...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Freire, Cristina, Fish, Richard J., Vilar, Rui, Di Sanza, Corinne, Grzegorski, Steven J., Richter, Catherine E., Shavit, Jordan A., Neerman-Arbez, Marguerite
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7656923/
https://ncbi.nlm.nih.gov/pubmed/33166405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001472
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