Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function

Pathologic blood clotting is a leading cause of morbidity and mortality in the developed world, underlying deep vein thrombosis, myocardial infarction, and stroke. Genetic predisposition to thrombosis is still poorly understood, and we hypothesize that there are many additional risk alleles and modi...

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Main Authors: Liu, Yang, Kretz, Colin A., Maeder, Morgan L., Richter, Catherine E., Tsao, Philip, Vo, Andy H., Huarng, Michael C., Rode, Thomas, Hu, Zhilian, Mehra, Rohit, Olson, Steven T., Joung, J. Keith, Shavit, Jordan A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2014
Teme:
Thrombosis and Hemostasis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125349/
https://ncbi.nlm.nih.gov/pubmed/24782510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-561027
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