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Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells

The activation mechanism of class B G-protein-coupled receptors (GPCRs) remains largely unknown. To characterize conformational changes induced by peptide hormones, we investigated interactions of the class B corticotropin-releasing factor receptor type 1 (CRF1R) with two peptide agonists and three...

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Pubblicato in:eLife
Autori principali: Seidel, Lisa, Zarzycka, Barbara, Zaidi, Saheem A, Katritch, Vsevolod, Coin, Irene
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542768/
https://ncbi.nlm.nih.gov/pubmed/28771403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27711
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