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Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells
The activation mechanism of class B G-protein-coupled receptors (GPCRs) remains largely unknown. To characterize conformational changes induced by peptide hormones, we investigated interactions of the class B corticotropin-releasing factor receptor type 1 (CRF1R) with two peptide agonists and three...
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| Publicat a: | eLife |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
eLife Sciences Publications, Ltd
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5542768/ https://ncbi.nlm.nih.gov/pubmed/28771403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27711 |
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