Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1

BRAF-V600E (1799T > A) is one of the most frequently reported driver mutations in multiple types of cancers, and patients with such mutations could benefit from selectively inactivating the mutant allele. Near this mutation site, there are two TTTN and one NGG protospacer-adjacent motifs (PAMs) f...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Yang, Meijia, Wei, Heng, Wang, Yuelong, Deng, Jiaojiao, Tang, Yani, Zhou, Liangxue, Guo, Gang, Tong, Aiping
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542387/
https://ncbi.nlm.nih.gov/pubmed/28918044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.05.009
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