Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1

BRAF-V600E (1799T > A) is one of the most frequently reported driver mutations in multiple types of cancers, and patients with such mutations could benefit from selectively inactivating the mutant allele. Near this mutation site, there are two TTTN and one NGG protospacer-adjacent motifs (PAMs) f...

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Bibliografski detalji
Izdano u:Mol Ther Nucleic Acids
Glavni autori: Yang, Meijia, Wei, Heng, Wang, Yuelong, Deng, Jiaojiao, Tang, Yani, Zhou, Liangxue, Guo, Gang, Tong, Aiping
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2017
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542387/
https://ncbi.nlm.nih.gov/pubmed/28918044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.05.009
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