Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1

BRAF-V600E (1799T > A) is one of the most frequently reported driver mutations in multiple types of cancers, and patients with such mutations could benefit from selectively inactivating the mutant allele. Near this mutation site, there are two TTTN and one NGG protospacer-adjacent motifs (PAMs) f...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Yang, Meijia, Wei, Heng, Wang, Yuelong, Deng, Jiaojiao, Tang, Yani, Zhou, Liangxue, Guo, Gang, Tong, Aiping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542387/
https://ncbi.nlm.nih.gov/pubmed/28918044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.05.009
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