THER-17. BRAF-V600E DEGRADATION AS A THERAPEUTIC STRATEGY IN BRAF-V600E MUTANT GLIOMAS

INTRODUCTION: Oncogenic, driver BRAF-V600E mutations are frequently found in pediatric gliomas. While small molecule inhibitors of BRAF and/or MEK kinases are showing early clinical efficacy against these tumors, no experimental strategies thus far have focused on the degradation of the mutant BRAF...

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Publicat a:Neuro Oncol
Autors principals: Zhao, Guisheng, Muldoon, Daniel, Mo, Xiulei, Tang, Cong, Fu, Haian, Gustafson, W Clay, Weiss, William A, Nicolaides, Theodore
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477326/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.224
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