Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage

Mitochondrial dysfunction in obesity and diabetes can be caused by excessive production of free radicals, which can damage mitochondrial DNA. Because mitochondrial DNA plays a key role in the production of ATP necessary for cardiac work, we hypothesized that mitochondrial dysfunction, induced by mit...

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Publicado no:Basic Res Cardiol
Main Authors: Guarini, Giacinta, Kiyooka, Takahiko, Ohanyan, Vahagn, Pung, Yuh Fen, Marzilli, Mario, Chen, Yeong Renn, Chen, Chwen Lih, Kang, Patrick T., Hardwick, James P., Kolz, Christopher L., Yin, Liya, Wilson, Glenn L., Shokolenko, Inna, Dobson, James G., Fenton, Richard, Chilian, William M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542063/
https://ncbi.nlm.nih.gov/pubmed/27040114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-016-0547-4
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