Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis

The efficacy of drugs targeting the CNS is influenced by their limited brain access, which can lead to complete pharmacoresistance. We recently reported a tissue-specific and selective upregulation of the multidrug efflux transporter ABCB1 or P-glycoprotein (P-gp) in the spinal cord of both patients...

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Bibliografiska uppgifter
I publikationen:Glia
Huvudupphovsmän: Qosa, Hisham, Lichter, Jessica, Sarlo, Mark, Markandaiah, Shashirekha S., McAvoy, Kevin, Richard, Jean-Philippe, Jablonski, Michael R., Maragakis, Nicholas J., Pasinelli, Piera, Trotti, Davide
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541958/
https://ncbi.nlm.nih.gov/pubmed/27158936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23003
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