An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1

Recent studies suggest that Cu/Zn superoxide dismutase (SOD1) could be pathogenic in both familial and sporadic amyotrophic lateral sclerosis (ALS) through either inheritable or nonheritable modifications. The presence of a misfolded WT SOD1 in patients with sporadic ALS, along with the recently rep...

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Detalles Bibliográficos
Main Authors: Guareschi, Stefania, Cova, Emanuela, Cereda, Cristina, Ceroni, Mauro, Donetti, Elena, Bosco, Daryl A., Trotti, Davide, Pasinelli, Piera
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324021/
https://ncbi.nlm.nih.gov/pubmed/22416121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115402109
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