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ARID1A-mutated ovarian cancers depend on HDAC6 activity
ARID1A , encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A and TP53 mutations are typically mutually exclusive. Therapeutic approaches that correlate with this genetic characteristic remain to be expl...
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| Pubblicato in: | Nat Cell Biol |
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| Autori principali: | , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5541905/ https://ncbi.nlm.nih.gov/pubmed/28737768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3582 |
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