ARID1A-mutated ovarian cancers depend on HDAC6 activity

ARID1A , encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A and TP53 mutations are typically mutually exclusive. Therapeutic approaches that correlate with this genetic characteristic remain to be expl...

詳細記述

保存先:
書誌詳細
出版年:Nat Cell Biol
主要な著者: Bitler, Benjamin G., Wu, Shuai, Park, Pyoung Hwa, Hai, Yang, Aird, Katherine M., Wang, Yemin, Zhai, Yali, Kossenkov, Andrew V., Vara-Ailor, Ana, Rauscher, Frank J, Zou, Weiping, Speicher, David W., Huntsman, David G., Conejo-Garcia, Jose R., Cho, Kathleen R., Christianson, David W., Zhang, Rugang
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541905/
https://ncbi.nlm.nih.gov/pubmed/28737768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3582
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