Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation

Synergistic cues from extracellular matrix and soluble factors are often obscure in differentiation. Here the rigidity of cross-linked collagen synergizes with retinoids in the osteogenesis of human marrow mesenchymal stem cells (MSCs). Collagen nanofilms serve as a model matrix that MSCs can easily...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Ivanovska, Irena L., Swift, Joe, Spinler, Kyle, Dingal, Dave, Cho, Sangkyun, Discher, Dennis E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541850/
https://ncbi.nlm.nih.gov/pubmed/28566555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-01-0010
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