Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1-mutated or IDH2-mutated solid tumours

INTRODUCTION: High-grade chondrosarcoma, high-grade glioma and intrahepatic cholangiocarcinoma are aggressive types of cancer with a dismal outcome. This is due to the lack of effective treatment options, emphasising the need for novel therapies. Mutations in the genes IDH1 and IDH2 (isocitrate dehy...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: Molenaar, Remco J, Coelen, Robert JS, Khurshed, Mohammed, Roos, Eva, Caan, Matthan WA, van Linde, Myra E, Kouwenhoven, Mathilde, Bramer, Jos AM, Bovée, Judith VMG, Mathôt, Ron A, Klümpen, Heinz-Josef, van Laarhoven, Hanneke WM, van Noorden, Cornelis JF, Vandertop, W Peter, Gelderblom, Hans, van Gulik, Thomas M, Wilmink, Johanna W
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541450/
https://ncbi.nlm.nih.gov/pubmed/28601826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2016-014961
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