IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance

Diarrhea is a host response to enteric pathogens, but its impact on pathogenesis remains poorly defined. By infecting mice with the attaching and effacing bacteria Citrobacter rodentium, we defined the mechanisms and contributions of diarrhea and intestinal barrier loss to host defense. Increased pe...

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Dades bibliogràfiques
Publicat a:Cell Host Microbe
Autors principals: Tsai, Pei-Yun, Zhang, Bingkun, He, Wei-Qi, Zha, Juan-Min, Odenwald, Matthew A., Singh, Gurminder, Tamura, Atsushi, Shen, Le, Sailer, Anne, Yeruva, Sunil, Kuo, Wei-Ting, Fu, Yang-Xin, Tsukita, Sachiko, Turner, Jerrold R.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541253/
https://ncbi.nlm.nih.gov/pubmed/28618266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.05.009
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