IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance

Diarrhea is a host response to enteric pathogens, but its impact on pathogenesis remains poorly defined. By infecting mice with the attaching and effacing bacteria Citrobacter rodentium, we defined the mechanisms and contributions of diarrhea and intestinal barrier loss to host defense. Increased pe...

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Détails bibliographiques
Publié dans:Cell Host Microbe
Auteurs principaux: Tsai, Pei-Yun, Zhang, Bingkun, He, Wei-Qi, Zha, Juan-Min, Odenwald, Matthew A., Singh, Gurminder, Tamura, Atsushi, Shen, Le, Sailer, Anne, Yeruva, Sunil, Kuo, Wei-Ting, Fu, Yang-Xin, Tsukita, Sachiko, Turner, Jerrold R.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541253/
https://ncbi.nlm.nih.gov/pubmed/28618266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2017.05.009
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