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Calcium-independent calmodulin binding and two-metal–ion catalytic mechanism of anthrax edema factor
Edema factor (EF), a key anthrax exotoxin, has an anthrax protective antigen-binding domain (PABD) and a calmodulin (CaM)-activated adenylyl cyclase domain. Here, we report the crystal structures of CaM-bound EF, revealing the architecture of EF PABD. CaM has N- and C-terminal domains and each domai...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC554124/ https://ncbi.nlm.nih.gov/pubmed/15719022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600574 |
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