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Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection
Edema factor (EF), a key virulence factor in anthrax pathogenesis, has calmodulin (CaM)-activated adenylyl cyclase activity. We have found that adefovir dipivoxil, a drug approved to treat chronic infection of hepatitis B virus, effectively inhibits EF-induced cAMP accumulation and changes in cytoki...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC365774/ https://ncbi.nlm.nih.gov/pubmed/14978283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306552101 |
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