NMR Structure-Based Optimization of Staphylococcus aureus Sortase A Pyridazinone Inhibitors

Staphylococcus aureus is a leading cause of hospital-acquired infections in the United States and is a major health concern as methicillin-resistant S. aureus (MRSA) and other antibiotic resistant strains are common. Compounds that inhibit the S. aureus sortase (SrtA) cysteine transpeptidase may fun...

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Publicat a:Chem Biol Drug Des
Autors principals: Chan, Albert H., Yi, Sung Wook, Weiner, Ethan M., Amer, Brendan R., Sue, Christopher K., Wereszczynski, Jeff, Dillen, Carly A., Senese, Silvia, Torres, Jorge Z., McCammon, J. Andrew, Miller, Lloyd S., Jung, Michael E., Clubb, Robert T.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540818/
https://ncbi.nlm.nih.gov/pubmed/28160417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12962
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