NMR Structure-Based Optimization of Staphylococcus aureus Sortase A Pyridazinone Inhibitors

Staphylococcus aureus is a leading cause of hospital-acquired infections in the United States and is a major health concern as methicillin-resistant S. aureus (MRSA) and other antibiotic resistant strains are common. Compounds that inhibit the S. aureus sortase (SrtA) cysteine transpeptidase may fun...

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Publicado en:Chem Biol Drug Des
Autores principales: Chan, Albert H., Yi, Sung Wook, Weiner, Ethan M., Amer, Brendan R., Sue, Christopher K., Wereszczynski, Jeff, Dillen, Carly A., Senese, Silvia, Torres, Jorge Z., McCammon, J. Andrew, Miller, Lloyd S., Jung, Michael E., Clubb, Robert T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540818/
https://ncbi.nlm.nih.gov/pubmed/28160417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12962
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