NMR Structure-Based Optimization of Staphylococcus aureus Sortase A Pyridazinone Inhibitors

Staphylococcus aureus is a leading cause of hospital-acquired infections in the United States and is a major health concern as methicillin-resistant S. aureus (MRSA) and other antibiotic resistant strains are common. Compounds that inhibit the S. aureus sortase (SrtA) cysteine transpeptidase may fun...

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Bibliographic Details
Published in:Chem Biol Drug Des
Main Authors: Chan, Albert H., Yi, Sung Wook, Weiner, Ethan M., Amer, Brendan R., Sue, Christopher K., Wereszczynski, Jeff, Dillen, Carly A., Senese, Silvia, Torres, Jorge Z., McCammon, J. Andrew, Miller, Lloyd S., Jung, Michael E., Clubb, Robert T.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540818/
https://ncbi.nlm.nih.gov/pubmed/28160417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12962
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