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Discovery of Staphylococcus aureus Sortase A Inhibitors Using Virtual Screening and the Relaxed Complex Scheme

Staphylococcus aureus is the leading cause of hospital-acquired infections in the United States. The emergence of multi-drug resistant strains of S. aureus has created an urgent need for new antibiotics. S. aureus uses the sortase A (SrtA) enzyme to display surface virulence factors suggesting that...

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Bibliografske podrobnosti
Main Authors: Chan, Albert H., Wereszczynski, Jeff, Amer, Brendan R., Yi, Sung Wook, Jung, Michael E., McCammon, J. Andrew, Clubb, Robert T.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841297/
https://ncbi.nlm.nih.gov/pubmed/23701677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12167
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