Glucocorticoids Hijack Runx2 to Stimulate Wif1 for Suppression of Osteoblast Growth and Differentiation

Inhibition of Runx2 is one of many mechanisms that suppress bone formation in glucocorticoid (GC)-induced osteoporosis (GIO). We profiled mRNA expression in ST2/Rx2(dox) cells after treatment with doxycycline (dox; to induce Runx2) and/or the synthetic GC dexamethasone (dex). As expected, dex typica...

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Veröffentlicht in:J Cell Physiol
Hauptverfasser: MORIMOTO, ERI, LI, MENG, KHALID, AYSHA B., KRUM, SUSAN A., CHIMGE, NYAM-OSOR, FRENKEL, BARUCH
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540653/
https://ncbi.nlm.nih.gov/pubmed/27061521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25399
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