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Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally-regulated gene signature related to clinical letrozole responsiveness
PURPOSE: To assess the clinical significance of the interaction between estrogen and Runx2 signaling, previously demonstrated in vitro. EXPERIMENTAL DESIGN: MCF7/Rx2(dox) BCa cells were treated with estradiol and/or doxycycline to induce Runx2, and global gene expression was profiled to define genes...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277803/ https://ncbi.nlm.nih.gov/pubmed/22147940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1530 |
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