High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles

Caspases of the non-canonical inflammasome (caspases-4/5/11) directly bind endotoxin (LOS/LPS) and can be activated in the absence of any co-factors. Models of LPS-induced caspase activation have postulated that 1:1 binding of endotoxin monomers to caspase trigger caspase oligomerization and activat...

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Bibliographic Details
Published in:Innate Immun
Main Authors: Wacker, Mark A, Teghanemt, Athmane, Weiss, Jerrold P, Barker, Jason H
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540323/
https://ncbi.nlm.nih.gov/pubmed/28409545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753425917695446
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