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High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles
Caspases of the non-canonical inflammasome (caspases-4/5/11) directly bind endotoxin (LOS/LPS) and can be activated in the absence of any co-factors. Models of LPS-induced caspase activation have postulated that 1:1 binding of endotoxin monomers to caspase trigger caspase oligomerization and activat...
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| Publié dans: | Innate Immun |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5540323/ https://ncbi.nlm.nih.gov/pubmed/28409545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753425917695446 |
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