2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A(2)

Cytosolic phospholipase A(2) (GIVA cPLA(2)) is the only PLA(2) that exhibits a marked preference for hydrolysis of arachidonic acid containing phospholipid substrates releasing free arachidonic acid and lysophospholipids and giving rise to the generation of diverse lipid mediators involved in inflam...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kokotou, Maroula G., Galiatsatou, Gerasimia, Magrioti, Victoria, Koutoulogenis, Giorgos, Barbayianni, Efrosini, Limnios, Dimitris, Mouchlis, Varnavas D., Satpathy, Banita, Navratil, Aaron, Dennis, Edward A., Kokotos, George
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539244/
https://ncbi.nlm.nih.gov/pubmed/28765606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07330-5
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