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Bitter taste receptor agonists alter mitochondrial function and induce autophagy in airway smooth muscle cells

Airway remodeling, including increased airway smooth muscle (ASM) mass, is a hallmark feature of asthma and COPD. We previously identified the expression of bitter taste receptors (TAS2Rs) on human ASM cells and demonstrated that known TAS2R agonists could promote ASM relaxation and bronchodilation...

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Bibliografiske detaljer
Udgivet i:Am J Physiol Lung Cell Mol Physiol
Main Authors: Pan, Shi, Sharma, Pawan, Shah, Sushrut D., Deshpande, Deepak A.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538869/
https://ncbi.nlm.nih.gov/pubmed/28450286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00106.2017
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