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Bitter taste receptors on airway smooth muscle bronchodilate by a localized calcium flux and reverse obstruction
Bitter taste receptors (TAS2Rs) of the tongue likely evolved to evoke signals for avoiding ingestion of plant toxins. We found expression of TAS2Rs on human airway smooth muscle (ASM) and considered these to be avoidance receptors for inhalants, leading to ASM contraction and bronchospasm. TAS2R ago...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3066567/ https://ncbi.nlm.nih.gov/pubmed/20972434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2237 |
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