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Bitter taste receptors on airway smooth muscle bronchodilate by a localized calcium flux and reverse obstruction

Bitter taste receptors (TAS2Rs) of the tongue likely evolved to evoke signals for avoiding ingestion of plant toxins. We found expression of TAS2Rs on human airway smooth muscle (ASM) and considered these to be avoidance receptors for inhalants, leading to ASM contraction and bronchospasm. TAS2R ago...

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書誌詳細
主要な著者: Deshpande, Deepak A, Wang, Wayne C H, McIlmoyle, Elizabeth L, Robinett, Kathryn S, Schillinger, Rachel M, An, Steven S, Sham, James S K, Liggett, Stephen B
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066567/
https://ncbi.nlm.nih.gov/pubmed/20972434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2237
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