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Bitter taste receptors on airway smooth muscle bronchodilate by a localized calcium flux and reverse obstruction

Bitter taste receptors (TAS2Rs) of the tongue likely evolved to evoke signals for avoiding ingestion of plant toxins. We found expression of TAS2Rs on human airway smooth muscle (ASM) and considered these to be avoidance receptors for inhalants, leading to ASM contraction and bronchospasm. TAS2R ago...

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Bibliografiska uppgifter
Huvudupphovsmän:	Deshpande, Deepak A, Wang, Wayne C H, McIlmoyle, Elizabeth L, Robinett, Kathryn S, Schillinger, Rachel M, An, Steven S, Sham, James S K, Liggett, Stephen B
Materialtyp:	Artigo
Språk:	Inglês
Publicerad:	2010
Ämnen:	Article
Länkar:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3066567/ https://ncbi.nlm.nih.gov/pubmed/20972434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2237
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Bitter taste receptors on airway smooth muscle bronchodilate by a localized calcium flux and reverse obstruction

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