Bitter taste receptors on airway smooth muscle bronchodilate by a localized calcium flux and reverse obstruction

Bitter taste receptors (TAS2Rs) of the tongue likely evolved to evoke signals for avoiding ingestion of plant toxins. We found expression of TAS2Rs on human airway smooth muscle (ASM) and considered these to be avoidance receptors for inhalants, leading to ASM contraction and bronchospasm. TAS2R ago...

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Main Authors: Deshpande, Deepak A, Wang, Wayne C H, McIlmoyle, Elizabeth L, Robinett, Kathryn S, Schillinger, Rachel M, An, Steven S, Sham, James S K, Liggett, Stephen B
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066567/
https://ncbi.nlm.nih.gov/pubmed/20972434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2237
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