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Bitter taste receptors on airway smooth muscle bronchodilate by a localized calcium flux and reverse obstruction

Bitter taste receptors (TAS2Rs) of the tongue likely evolved to evoke signals for avoiding ingestion of plant toxins. We found expression of TAS2Rs on human airway smooth muscle (ASM) and considered these to be avoidance receptors for inhalants, leading to ASM contraction and bronchospasm. TAS2R ago...

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Autors principals: Deshpande, Deepak A, Wang, Wayne C H, McIlmoyle, Elizabeth L, Robinett, Kathryn S, Schillinger, Rachel M, An, Steven S, Sham, James S K, Liggett, Stephen B
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066567/
https://ncbi.nlm.nih.gov/pubmed/20972434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2237
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