Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through a TLR4-TRIF-PI3K signaling pathway

Monophosphoryl lipid A (MPLA) is a detoxified derivative of LPS that induces tolerance to LPS and augments host resistance to bacterial infections. Previously, we demonstrated that LPS inhibits [Formula: see text] absorption in the medullary thick ascending limb (MTAL) through a basolateral Toll-lik...

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Bibliographic Details
Published in:Am J Physiol Renal Physiol
Main Authors: Watts, Bruns A., George, Thampi, Sherwood, Edward R., Good, David W.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538844/
https://ncbi.nlm.nih.gov/pubmed/28356284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00064.2017
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