Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through induction of Tollip and negative regulation of IRAK-1

LPS inhibits [Formula: see text] absorption in the medullary thick ascending limb (MTAL) through a Toll-like receptor 4 (TLR4)-myeloid differentiation factor 88 (MyD88)-extracellular signal-regulated kinase (ERK) pathway that is upregulated by sepsis. Pretreatment with the nontoxic immunomodulator m...

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Publicado en:Am J Physiol Renal Physiol
Autores principales: Watts, Bruns A., Tamayo, Esther, Sherwood, Edward R., Good, David W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766623/
https://ncbi.nlm.nih.gov/pubmed/31241993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00170.2019
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