Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice

Copper-transporting ATPase 2 (ATP7B) is essential for mammalian copper homeostasis. Mutations in ATP7B result in copper accumulation, especially in the liver, and cause Wilson disease (WD). The major role of hepatocytes in WD pathology is firmly established. It is less certain whether the excess Cu...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Muchenditsi, Abigael, Yang, Haojun, Hamilton, James P., Koganti, Lahari, Housseau, Franck, Aronov, Lisa, Fan, Hongni, Pierson, Hannah, Bhattacharjee, Ashima, Murphy, Robert, Sears, Cynthia, Potter, James, Wooton-Kee, Clavia R., Lutsenko, Svetlana
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538836/
https://ncbi.nlm.nih.gov/pubmed/28428350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00312.2016
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