Systemic deletion of Atp7b modifies the hepatocytes’ response to copper overload in the mouse models of Wilson disease

Wilson disease (WD) is caused by inactivation of the copper transporter Atp7b and copper overload in tissues. Mice with Atp7b deleted either globally (systemic inactivation) or only in hepatocyte recapitulate various aspects of human disease. However, their phenotypes vary, and neither the common re...

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Publicado en:Sci Rep
Main Authors: Muchenditsi, Abigael, Talbot, C. Conover, Gottlieb, Aline, Yang, Haojun, Kang, Byunghak, Boronina, Tatiana, Cole, Robert, Wang, Li, Dev, Som, Hamilton, James P., Lutsenko, Svetlana
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7952580/
https://ncbi.nlm.nih.gov/pubmed/33707579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84894-3
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