Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer

Metastasis is a complex biological process that has been difficult to delineate in human colorectal cancer (CRC) patients. A major obstacle in understanding metastatic lineages is the extensive intra-tumor heterogeneity at the primary and metastatic tumor sites. To address this problem, we developed...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Leung, Marco L., Davis, Alexander, Gao, Ruli, Casasent, Anna, Wang, Yong, Sei, Emi, Vilar, Eduardo, Maru, Dipen, Kopetz, Scott, Navin, Nicholas E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538546/
https://ncbi.nlm.nih.gov/pubmed/28546418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.209973.116
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