Src activity is modulated by oxaliplatin and correlates with outcomes after hepatectomy for metastatic colorectal cancer

BACKGROUND: The nonreceptor tyrosine kinase Src regulates multiple pathways critical to tumor proliferation, chemoresistance, and epithelial-to-mesenchymal transition. It is robustly activated after acute oxaliplatin exposure and in acquired oxaliplatin resistance in vitro and in vivo, but not after...

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Bibliografiska uppgifter
Huvudupphovsmän: Kopetz, Scott, Morris, Van K, Parikh, Nila, Overman, Michael J, Jiang, Zhi-Qin, Maru, Dipen, Elvin, Paul, Gallick, Gary
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167273/
https://ncbi.nlm.nih.gov/pubmed/25208577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-660
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