Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Carcinoma Cells is Mediated by Oxidative Stress

Chemotherapeutic regimens for the treatment of colorectal cancer generally include oxaliplatin, although inherent and acquired resistance is common. One potential mediator of oxaliplatin sensitivity is the non-receptor protein tyrosine kinase, Src, the activity of which correlates with disease stage...

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Detalhes bibliográficos
Main Authors: Kopetz, Scott, Lesslie, Donald P., Dallas, Nikolas A., Park, Serk I., Johnson, Marjorie, Parikh, Nila U., Kim, Michael P., Abbruzzese, James L., Ellis, Lee M., Chandra, Joya, Gallick, Gary E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709758/
https://ncbi.nlm.nih.gov/pubmed/19383922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2246
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