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Inhibition of Src Expression and Activity Inhibits Tumor Progression and Metastasis of Human Pancreatic Adenocarcinoma Cells in an Orthotopic Nude Mouse Model

The nonreceptor protein tyrosine kinase Src is overexpressed in 70% of pancreatic adenocarcinomas. Here, we describe the effect of molecular and pharmacological down-regulation of Src on incidence, growth, and metastasis of pancreatic tumor cells in an orthotopic model. Src expression in L3.6pl huma...

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Bibliografiske detaljer
Main Authors: Trevino, Jose G., Summy, Justin M., Lesslie, Donald P., Parikh, Nila U., Hong, David S., Lee, Francis Y., Donato, Nicholas J., Abbruzzese, James L., Baker, Cheryl H., Gallick, Gary E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606527/
https://ncbi.nlm.nih.gov/pubmed/16507911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050570
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