Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy

Myotonic dystrophy type 1 (DM1) is a CTG microsatellite expansion (CTG(exp)) disorder caused by expression of CUG(exp) RNAs. These mutant RNAs alter the activities of RNA processing factors, including MBNL proteins, leading to re-expression of fetal isoforms in adult tissues and DM1 pathology. While...

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Foilsithe in:Genes Dev
Main Authors: Thomas, James D., Sznajder, Łukasz J., Bardhi, Olgert, Aslam, Faaiq N., Anastasiadis, Zacharias P., Scotti, Marina M., Nishino, Ichizo, Nakamori, Masayuki, Wang, Eric T., Swanson, Maurice S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2017
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538435/
https://ncbi.nlm.nih.gov/pubmed/28698297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.300590.117
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