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Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates
Mitotic duration is determined by activation of the anaphase-promoting complex/cyclosome (APC/C) bound to its coactivator, Cdc20. Kinetochores, the microtubule-interacting machines on chromosomes, restrain mitotic exit when not attached to spindle microtubules by generating a Cdc20-containing comple...
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| Pubblicato in: | Genes Dev |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5538432/ https://ncbi.nlm.nih.gov/pubmed/28698300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.302067.117 |
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