CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations

Intratumor genetic heterogeneity underlies the ability of tumors to evolve and adapt to different environmental conditions. Using CRISPR/Cas9 technology and specific DNA barcodes, we devised a strategy to recapitulate and trace the emergence of subpopulations of cancer cells containing a mutation of...

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Publicado en:Mol Cell
Main Authors: Guernet, Alexis, Mungamuri, Sathish Kumar, Cartier, Dorthe, Sachidanandam, Ravi, Jayaprakash, Anitha, Adriouch, Sahil, Vezain, Myriam, Charbonnier, Françoise, Rohkin, Guy, Coutant, Sophie, Yao, Shen, Ainani, Hassan, Alexandre, David, Tournier, Isabelle, Boyer, Olivier, Aaronson, Stuart A., Anouar, Youssef, Grumolato, Luca
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537739/
https://ncbi.nlm.nih.gov/pubmed/27453044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.06.017
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